كلية الصيدلة

مشاريع التخرج بالسنة الميلادية

2015

Graduation Projects:

1- Preparation and evaluation of ibuprofen gels: Effect of different variables (Fall 2015).

(full article)

Supervisors: Prof. Ibrahim Elbagoury ; Dr. Mohamed Raslan.

Students: Alnahia KS, Alrewely AM, Alenzy AA,  Alenzy KS, Alenzy AM, Alasery OA.

Abstract: The objective of this study was to use solid dispersion incorporated gel approach to improve the transdermal delivery of Ibuprofen. Ibuprofen solid dispersions were prepared by fusion of drug: polyethylene glycol 6000 (PEG6000) in ratios 1:1and 1:2. The prepared solid dispersions were evaluated for dissolution. Depending on dissolution study, solid dispersion of ibuprofen: PEG 6000 prepared in 1:2 ratio was selected, incorporated into different gel bases [Methyl Cellulose (MC),  Hydroxy Propyl Methyl Cellulose (HPMC) and Carbapol 940] and compared with marketed Ibuprofen gel (Profinal® gel). The release of Ibuprofen after 60 min from Ibuprofen solid dispersions was 94.89%, 86.30% while the release of pure drug after the same time was 10.45 %.  The marketed gel (Profinal® gel) showed a highest dissolution than solid dispersion incorporated gels. Considered overall, Solid dispersion of Ibuprofen with PEG 6000 increased the dissolution and skin permeability of Ibuprofen but less therapeutic effective than the marketed gel (Profinal® gel).

 

2- Comparative study between commercial tablets containing Diclofenac Sodium (50 mg) (Fall 2015). (full article)

Supervisors: Prof. Ibrahim Elbagoury ; Dr. Mohamed Raslan.

Students: Elshamry NR, Elshamry HA, Elshahry AH, Elrwely ME.

 Abstract: The objective of this study was to compare between three different brands of Diclofenac Sodium 50 mg tablets (Voltaren®, Rofenac® and Diclomax®) available in public pharmacies in Kingdom Saudi Arabia (KSA).  The study was done by quality control tests like; weight variation, thickness, diameter, hardness, friability, hardness, disintegration and dissolution on branded tablets. The results of all marketed products complied with the official specifications. By comparing the quality results of branded tablets, the best brand was Voltaren® 50 mg tablets while Diclomax® 50 mg tablets was the worst.

 

3- Preparation and characterization of poorly soluble drug in different gel bases for transdermal (Fall 2015).

(full article)

Supervisors: Prof. Ibrahim Elbagoury; Dr. Mohamed Elmowafy.

Students: Abdelraouf Elrehaily; Adel Elharby; Tarek Ali; Ahmed Elelian; Adel Elsemaihy; Naif Elgabry

Abstract: Aspirin (acetylsalicylic acid) has become the gold standard to which newer antiplatelet drugs are compared for reducing risks of cardiovascular diseases, while keeping low cost. Oral aspirin has a repertoire of gastrointestinal side effects even at low doses and requires high frequent dosing because it undergoes extensive presystemic metabolism. Transdermal delivery offers an alternative route that bypasses the gut and may be more convenient and safer for aspirin delivery especially during long-term use. So, the aim of this study was to use three penetration enhancers (oleic acid, propylene glycol and propanol) to improve the transdermal delivery of acetylsalicylic acid. The mixtures were incorporated into two gel bases; Methyl Cellulose (MC) and Carbapol 940. The prepared formulations were tested for drug content, organoleptic characters and in vitro drug release. Drug content data showed good results (85-94%). In vitro release data showed the maximum drug release was from carbopol 940 using propylene glycol as penetration enhancer (88%) after 3h. Release kinetics of prepared formulations revealed that all formulations follow diffusion model except C5 which exhibited zero order kinetic. 

 

4- Development of nanostructured lipid carrier for improvement of solubility of poorly soluble drug (Fall 2015). (full article)

Supervisors:Prof. Ibrahim Elbagoury; Dr. Mohamed Elmowafy.

Students: Omar Elhegaily; Ibrahim Elharby; Omar Elaoud; Saleh Elanzy; Abdo Mostafa; Tawfeeq Elfify;  Wael Elserehy. 

Abstract: Carbamazepine is used in the treatment of epilepsy, but it is having limitations such as low solubility leading to lower oral bioavailability. Aiming to improve its poor solubility and oral bioavailability, Carbamazepine NLCs were prepared by high speed homogenization followed by ultrasonication and in vitro evaluated. The prepared NLCs were tested for encapsulation efficiency (EE%) and in vitro drug release. EE% lied between 75 % and 86.2%. In vitro release data revealed sustained release behavior and about 24% of the drug released after 3h. Release kinetics of prepared NLCs revealed that all NLCs follow zero order reaction. 

 

Review Articles:

1- Different Approaches Have been Performed to Enhance Transdermal Delivery of Drugs (Fall 2015).(full article)

Supervisors: Prof. Ibrahim Elbagoury ; Dr. Mohamed Raslan.

Students: Alnahia KS, Alrewely AM, Alenzy AA,  Alenzy KS, Alenzy AM, Alasery OA.

Abstract: There is considerable interest in the skin as a site of drug application both for local and systemic effect. However, the skin, in particular the stratum corneum, poses a formidable barrier to drug penetration thereby limiting topical and transdermal bioavailability. Rather than its barrier properties, strategies have been developed to deliver the drugs through the skin. Transdermal drug delivery systems allow delivery of a drug into the systemic circulation via permeation through skin layers at a controlled rate. In addition to the currently marketed formulations, new drugs are being formulated using the transdermal system because of the inherent advantage of administration by this route. This review describes enhancement techniques of permeation of drugs through skin, which can be enhanced by various methods including physical, electrical, chemical and formulation approaches. Studies have been carried out to find safe and appropriate permeation enhancers to promote the percutaneous absorption of a number of drugs. The mechanism of action of penetration enhancement techniques and their potential for clinical application are described in this review.

 

2- Quality Control Tests for Solid Dosage Forms (Fall 2015).(full article)

Supervisors: Prof. Ibrahim Elbagoury ; Dr. Mohamed Raslan.

Students: Elshamry NR, Elshamry HA, Elshahry AH, Elrwely ME.

Abstract: The main criteria for quality of any drug in solid dosage forms (tablets and capsules) are its safety, potency, efficacy, stability, patient acceptability and regulatory compliance. At the product design and formulation stage the comply with to fulfill quality requirements, have to determine and the target for quality must be set. In-process quality control (IPQC) tests are strongly related to final products quality because checks performed during production in order to monitor and if necessary to adjust the process to ensure that the product conforms to its specification are the key for good quality pharmaceutical tablets. The purposes of IPQC are to produce a perfect finished product by preventing or eliminating errors at every stage in production. After the manufacturing process is complete, finished product quality control (FPQC) tests for pharmaceutical tablets, capsules and suppositories are performed with respect to specification of the pharmacopoeias in order to check that the quality parameters are within acceptance limits or not. The aim of this study is to provide in-process and finished products quality control tests for pharmaceutical tablets and capsules according to pharmacopoeias.


3- Transdermal Drug Delivery Systems; Review Article

(full article

Supervisors: Prof. Ibrahim Elbagoury ; Dr. Mohammed Elmowafy.

Students: Abdelraouf Elrehaily, Adel Elharby, Tarek Ali, Ahmed Elelian, Adel Elsemaihy and Naif Elgabry

Abstract

 

Transdermal drug delivery system is the system in which the delivery of the active ingredients of the drug occurs through the skin. Transdermal drug delivery system can improve the therapeutic efficacy and safety of the drugs because drug delivered through the skin at a predetermined and controlled rate. Skin is an effective medium from which absorption of the drug takes place and enters the circulatory system. Various types of Transdermal patches are used that delivered the specific dose of medication directly into the blood stream. This review article covers a brief outline of the transdermal drug delivery system, advantages over conventional drug delivery system, Layers of the skin, various components of transdermal patch, penetration enhancers, and evaluation of transdermal system and applications of Transdermal patch.

4- Nanostructured lipid carrier (NLC) as recent drug carrier

(full Article)

Supervisors: Prof. Ibrahim Elbagoury ; Dr. Mohammed Elmowafy.

Students: Omar Elhegaily, Ibrahim Elharby, Omar Elaoud, Saleh Elanzy, Abdo Mostafa, Tawfeeq Elfify and Wael Elserehy

Abstract

 

Nanostructured lipid carriers (NLCs) are drug-delivery systems composed of both solid and liquid lipids as a core matrix. It was shown that NLCs reveal some advantages for drug therapy over conventional carriers, including increased solubility, the ability to enhance storage stability, improved permeability and bioavailability, reduced adverse effect, prolonged half-life, and tissue-targeted delivery. NLCs have attracted increasing attention in recent years. This review describes the structures, preparation techniques, and application of NLCs are systematically elucidated in this review. The potential of NLCs to be used for different administration routes is highlighted. Relevant issues for the introduction of NLCs to market, including pharmaceutical and cosmetic applications, are discussed. 

 

 

2016

Graduation Projects:

1- Preparation and characterization of Carbamazepine nanospheres (Spring 2016).

Supervisors: Prof. Ibrahim Elbagoury ; Dr. Mohamed Raslan.

Students: Nawaf Alenzy, Talal Alenzy, Adel Algohany, Adel Alenzy, Naief Alharby.

Scope of work: Enhancement of solubility and sustaining the release of Carbamazepine.

Research Contents:  

1- General information about nanospheres.

2- Preparation and characterization of Carbamazepine loaded nanospheres.

3- Determination of encapsulation efficiency and in vitro release

 

2- Formulation and characterization of Ibuprofen loaded nanocapsules incorporated gels (Spring 2016).

Supervisors: Prof. Ibrahim Elbagoury ; Dr. Mohamed Raslan.

Students: Mohamed Alasmary, Abd Allah Alahmary, Abdel Rahman Almontashery, Mohamed Almotarad, Saad Alomrany.

Scope of work:

-  Enhancement of solubility of Ibuprofen.

- Decreasing Ibuprofen related adverse effects through transdermal delivery as an alternative to oral administration. 

Research Contents :  

1- General information about polymeric nanoparticles.

2- Preparation and characterization of Ibuprofen loaded nanocapsules.

3- Incorporation of the prepared Ibuprofen loaded nanocapsules into different gel bases.

4- Characterization the prepared gels.

 

3- Formulation, release characteristics and in-vitro evaluation of ibuprofen suppositories (Spring 2016).

Supervisors: Prof. Ibrahim Elbagoury; Dr. Khaled Shalaby.

Students: Khaled Alenzy; Gafar Almatar; Basem Alradeny; Fawaz Alenzy; Naief Alsharef.

Scope of work: Preparation of ibuprofen loaded different suppository bases and determination of the most effective formulation.

Research Contents:

1- Preparation of different suppository bases containing ibuprofen.

2- Quality control testing of prepared suppositories according to our laboratory credentials.

3- Comparison between prepared formulations and corresponding market product.

 

 

4- Preparation and in vitro evaluation of paracetamol suppositories (Spring 2016).

Supervisors: Prof. Ibrahim Elbagoury; Dr. Khaled Shalaby.

Students: Khaled Alenzy; Gafar Almatar; Basem Alradeny; Fawaz Alenzy; Naief Alsharef.

Scope of work: Preparation of polyethyleneglycol based suppositories containing paracetamol and determination of the most effective formulation.

 

Research Contents:

1- Preparation of different suppository bases containing paracetamol.

2- Quality control testing of prepared suppositories according to our laboratory credentials.

3- Comparison between prepared formulations and corresponding market product.

5- Formulation and in vitro evaluation of topical sulphacetamide gel bases (Spring 2016).

Supervisors: Ibrahim Elbagoury; Mohamed Elmowafy.

Students: Dagy Aliamy; Dawod Aliamy; Mohamed Almotarad; Abdel Rahman Alenzy; Ali Alenzy.

Scope of work:Enhancement of ibuprofen solubility.

Research Contents:

1- Preparation of different nanostructured lipid carrier by high shear homogenization flowed by sonication.

2- Determination of encapsulation efficiency and in vitro release.

 

6- Enhancement of water solubility of ibuprofen by Nanostructured lipid carrier (Spring 2016).

Supervisors: Ibrahim Elbagoury; Mohamed Elmowafy.

Students: Shaiem Alrwely; Samy Alomary; Faiez Almotery; Abd Allah Alsatamy; Mohsen Alharby; Abdel Rahman Alharby.

Scope of work: Determination of the most effective gel base.

Research Plan:

1- Preparation of different gel bases containing sulphacetamide.

2- Characterization of prepared gels according to our laboratory credentials.

 

Review Articles:

1- Enhancement of skin permeability using polymeric nanoparticles (Spring 2016).

Supervisors: Prof. Ibrahim Elbagoury ; Dr. Mohamed Raslan.

Students: Mohamed Alasmary, Abd Allah Alahmary, Abdel Rahman Almontashery, Mohamed Almotarad, Saad Alomrany.

Abstract: Polymeric nanoparticles are nanocarriers present a size ranging from 10 to 1000 nm and are employed to carry drugs by incorporation or absorption. Two different types of polymeric nanoparticles may be distinguished depending upon the method of preparation: nanospheres and nanocapsules. Nanocapsules are systems in which the bioactive compound is soluble in the core, confined to a cavity surrounded by a polymer membrane, while nanospheres are matrix systems in which the drug is physically and uniformly dispersed. Polymeric nanoparticles  have shown great potential as drug delivery systems for topical, oral or systemic applications. They have attracted considerable attention as potential drug delivery systems, increasing therapeutic efficacy and reducing side effects of a variety of drugs associated with these systems. They present unique characteristics as drug carriers including high drug encapsulation efficiency, the ability to prolong drug release because of the protection of the drug against chemical and enzymatic degradation, and the capacity to reduce the systemic adverse effects and the risks of toxicity with the purpose of minimizing the number of administrations for a better patient compliance. Polymeric nanoparticles show great promise in the treatment of a wide range of diseases due to the flexibility in which their structures can be modified.

2- Rectal route as important route to avoid first pass effect and gastric irritation of Ibuprofen and Paracetamol drugs (Spring 2016).

Supervisors: Prof. Ibrahim Elbagoury; Dr. Khaled Shalaby.

Students: Abdel Aziz Alenzy; Ahmed Alatawy; Soliman Alenzy; Salem Alashesh; Abd Allah Alnakhly.

3- The role of chemical penetration enhancers in passing through striatum corneum (the main barrier of cutaneous delivery) (Spring 2016).

Supervisors: Ibrahim Elbagoury; Mohamed Elmowafy.

Students: Dagy Aliamy; Dawod Aliamy; Mohamed Almotarad; Abdel Rahman Alenzy; Ali Alenzy.

4- Methods of preparation of NLC (Spring 2016).

Supervisors: Ibrahim Elbagoury; Mohamed Elmowafy.

Students: Shaiem Alrwely; Samy Alomary; Faiez Almotery; Abd Allah Alsatamy; Mohsen Alharby; Abdel Rahman Alharby.

 

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